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Goal-directed haemodynamic therapy during general anaesthesia for noncardiac surgery: a systematic review and meta-analysis.

Br J Anaesth · 2022 · PMC8900265 · PMID 34916049

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There were some signals that GDHT protocols with targets based on preload variation by the respiratory cycle demonstrated better outcomes, but, again, this result should be interpreted carefully as the test for subgroup differences did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.