Prevalence of <i>Clostridium difficile</i> Infection in the Hematopoietic Transplantation Setting: Update of Systematic Review and Meta-Analysis.

Front Cell Infect Microbiol · 2022 · PMC8900492 · PMID 35265530

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an increasing trendno p-value reported

An earlier systematic review of published literature until 2014 showed that the pooled prevalence of CDI among 12,025 HSCT patients was 7.9%, and an increasing trend of CDI diagnosis was also found worldwide and across studies conducted in North America over the last 34 years ( Zacharioudakis et al., 2014 ).

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did not reach statistical significanceno p-value reported

In our analysis, we observed that most of the studies (72.1%, 31/43) were obtained from North America, and the estimated prevalence of CDI among HSCT patients in North America was 14.1%, which was significantly higher than that in Europe (10.7%) but did not reach statistical significance than that in Asia (11.6%).

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