NBI-921352, a first-in-class, Na<sub>V</sub>1.6 selective, sodium channel inhibitor that prevents seizures in <i>Scn8a</i> gain-of-function mice, and wild-type mice and rats.

Elife · 2022 · PMC8903829 · PMID 35234610

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showed a trendno p-value reported

In contrast, fast-firing inhibitory interneuron firing was not impaired and actually showed a trend toward increasing (although not statistically significant).

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