Environmental enrichment enhances patterning and remodeling of synaptic nanoarchitecture as revealed by STED nanoscopy.

Ctr housed mice showed a clear trend: the longer the measurement interval, the greater the morphological change ( Figure 5C ); the percentage of PSD95 nanoorganization showing no change decreased from ~40% to ~10%, while the percentage for strong changes nearly tripled for Ctr.

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While the variance is lower for both, PC1 and PC2 in EE housed mice this decrease is highly significant only for PC2, which indicates a strong decrease in negatively correlated changes.

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