Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stress.

6 h), a downregulation of Cldn5 in Stress WT and a clear trend to decrease in both Sphk2−/− groups (p = 0.05) compared to Control WT (Fig. 6 i), and a lowered Cldn7 expression for Stress Sphk2−/− in comparison to Stress WT (Fig. 6 j).

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