Tumor-Derived Extracellular Vesicles Activate Normal Human Fibroblasts to a Cancer-Associated Fibroblast-Like Phenotype, Sustaining a Pro-Tumorigenic Microenvironment.

Front Oncol · 2022 · PMC8905682 · PMID 35280782

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The invasion assay performed with the modified Boyden chamber showed that both fibroblasts treated with EVs 30′ and EVs 18h showed a trend to a greater invasiveness capacity (respectively +101% and +30%) as compared to NHDF ( Figure 5A ), but only NHDF 30′ had a statistically significant greater ability if compared to NHDF.

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