Activation of LXR Nuclear Receptors Impairs the Anti-Inflammatory Gene and Functional Profile of M-CSF-Dependent Human Monocyte-Derived Macrophages.

Compared to CNT M-MØ, protein analysis revealed that GW-M-MØ has significantly reduced levels of MAF ( Figure 5B ) and MAFB ( Figure 5C ), although the latter did not reach statistical significance.

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Interestingly, gene ontology analysis (Enrichr) of the 313 genes downregulated in GW-M-MØ showed a strong enrichment in MAF- and MAFB-dependent genes, as well as a highly significant enrichment of the genes that define the profile of “large TAM” from colorectal liver metastasis ( 42 ) ( GSE131353 , Figure 2G ), thus lending further relevance to the monocyte-conditioning ability of LXR modulators.

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