Functional Antagonism of Junctional Adhesion Molecule-A (JAM-A), Overexpressed in Breast Ductal Carcinoma In Situ (DCIS), Reduces HER2-Positive Tumor Progression.

Functionally, JBS2 exerted concentration-dependent reductions in the viability of estrogen receptor (ER)-negative HER2-positive SUM-225 breast cancer cells, a DCIS-like cell model ( Figure 2 E), and it showed a trend to reduce viability in a primary culture from a DCIS patient ( Figure 2 F; p = ns).

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