Changes in Non-Deamidated versus Deamidated Epitope Targeting and Disease Prediction during the Antibody Response to Gliadin and Transglutaminase of Infants at Risk for Celiac Disease.

The anti-gliadin antibodies produced at the age of 6 months tended to have slightly higher binding strength (i.e., having a lower K D ) for the non-deamidated (γGlia_Q) peptide, whereas at the time of CeD diagnosis, the binding strength was higher for the deamidated (γGlia_E) peptide ( Figure 4 A), but the difference in mean K D values did not reach statistical significance.

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