The PDI showed a trend similar to the one observed for the size, i.e., it was possible to notice an initial increase, passing from 0.17 ± 0.08 in day 0 to 0.29 ± 0.02 in day 1, due to the aggregation during the freezing and thawing process, and only a slow trend towards higher values after that.
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Pioglitazone-Loaded PLGA Nanoparticles: Towards the Most Reliable Synthesis Method.
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