Risk of acute kidney injury associated with anti-pseudomonal and anti-MRSA antibiotic strategies in critically ill patients.

Despite a trend toward lower risk of KRT within 30 days, exposure to a non-PTZ or non-vancomycin combination did not reach statistical significance (OR, 0.51; 95% CI, 0.26–1.01; p = NS).

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Instead, we found a statistically significant increased risk of KRT initiation within 30 days associated with PTZ and vancomycin exposure, with a notable trend toward a similar risk with the PTZ-vancomycin combination.

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