Discovery of a functionally selective ghrelin receptor (GHSR<sub>1a</sub>) ligand for modulating brain dopamine.

Proc Natl Acad Sci U S A · 2022 · PMC8915830 · PMID 35239443

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did not reach statistical significanceno p-value reported

At 10 μM, N8279 produced an ∼3-fold increase in ghrelin’s potency but did not reach statistical significance ( Fig. 1 G ).

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a statistical trendno p-value reported

L585 displayed a similar profile, except that it had reduced potency at Gα i1 and only a statistical trend for reduced potency at Gα 12 .

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