Strikingly, the magnitude of p53 rapid accumulation followed a clear trend that correlated with the sequence homology of the species-specific p53 to human p53, with mouse p53 demonstrating a greater order of magnitude followed by elephant shark, lamprey, and finally, trichoplax p53 ( SI Appendix , Fig.
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Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity.
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