Hereditary alpha-tryptasemia modifies clinical phenotypes among individuals with congenital hypermobility disorders.

2 , 3 , 4 , 5 , 6 , 7 , 12 , 13 Interestingly, there was also an increased prevalence of anaphylaxis and pruritus among individuals with joint hypermobility and HαT, phenotypes also strongly linked to HαT in previous studies 2 , 3 , 5 , 7 ; however, the sample size was limited, and these did not reach statistical significance when adjusting for multiple comparisons (OR 5.9 [1.1–26.0]; p = 0.07, adjusted p = 0.98) and (OR 1.9 [-0.5–6.5]; p = 0.5, adjusted p >0.99), respectively.

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