Effects of liraglutide vs. lifestyle changes on soluble suppression of tumorigenesis-2 (sST2) and galectin-3 in obese subjects with prediabetes or type 2 diabetes after comparable weight loss.

Moreover, overall (n = 40), a 3% (95%CI − 29% to 23%, p = 0.81) reduction in serum hs-TnI was observed after intervention, due to a 19% (95%CI − 27% to 66%; p = 0.29) increase in the lifestyle arm, and a significant 25% decrease (95%CI − 48% to − 2%; p = 0.033) in the liraglutide arm, with a between-group difference in ∆%hs-TnI at the limits of significance, both unadjusted (p = 0.080) and adjusted for age, sex, basal triglycerides, basal VAT and basal waist circumference (beta = − 0.53, standard deviation 0.30, p = 0.083) (Fig. 4 C) .

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