Increased blastomere number is associated with higher live birth rate in day 3 embryo transfer.

Discussion Over the past decade, there has been an increasing trend of extending culture from cleavage-stage embryos to blastocysts [ 18 ].

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The odds of positive hCG test (aOR 0.67, 95% CI 0.49–0.93; P = 0.018) and clinical pregnancy (aOR 0.65, 95% CI 0.46–0.91; P = 0.012) were also decreased in the 7-cell group as compared with that in the reference group, while the difference in LBR (aOR 0.74, 95% CI 0.52–1.06; P = 0.106) failed to reach statistical significance.

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While the authors attributed it to the continuously rapid developmental speed of fast-cleaving embryos, this hypothesis, as they acknowledged, requires more researches for validation due to the borderline significance.

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