Olokizumab, a monoclonal antibody against interleukin 6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by methotrexate: efficacy and safety results of a randomised controlled phase III study.

An analysis of RA trials of anti-TNF biologics showed a trend towards decreasing rate of radiographic progression, possibly due to more effective patient management, and to reliably show a positive radiographic effect one must include large numbers of patients on PBO, a possible ethical issue. 25 Third, this study was conducted in a limited geographical location with limited racial diversity and its findings should be confirmed in other phase III controlled trials that include a more diverse patient population.

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