A Clinical Review on Paroxetine and Emerging Therapies for the Treatment of Vasomotor Symptoms.

44 However, a multicenter randomized study to evaluate lowest effective dose of E4 for vasomotor symptoms found 15 mg of estetrol as the minimum effective dose, while lower doses failed to reach statistical significance. 44 Early studies suggested that estetrol was a weak estrogen; however, advancement of our understanding has shown that E4 has varying pharmacodynamic and metabolic properties as compared to estradiol. 43 , 45 Estetrol has high oral bioavailability, does not enter enterohepatic circulation, and is

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