Targeting CD96 overcomes PD-1 blockade resistance by enhancing CD8+ TIL function in cervical cancer.

IFN-γ, GZMB and TNF-α, the levels of which were extremely low or high at baseline, tended to increase after dual-blockade treatment, but the difference did not reach statistical significance ( figure 6F , online supplemental figure 8 ). 10.1136/jitc-2021-003667.supp13 Supplementary data Therefore, in addition to curing mice of their implanted tumors, blocking CD96 in combination with PD-1 promoted a durable protective antitumor CD8+ T-cell response in a preclinical mouse model.

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