BRCA1 mutations in high-grade serous ovarian cancer are associated with proteomic changes in DNA repair, splicing, transcription regulation and signaling.

Sci Rep · 2022 · PMC8924168 · PMID 35292711

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The analysis of RNA sequencing data from the TCGA data set 1 showed a trend towards reduced mRNA levels of the CK2 alpha subunit (CSNK2A), CLK and SRPK kinase members in BRCA1mut tumors, thus reinforcing the notion that BRCA1 modulates the transcriptional regulation of these kinases (Fig. 4 D–F).

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