The Synthesis of Conjugated Peptides Containing Triazole and Quinolone-3-Carboxamide Moieties Designed as Anticancer Agents.

Moreover, the toxicity of C2 conjugates, i.e .Cipro-C2 and triazole-C2, at 1000 μM concentration on LNCaP cells was more significant ( p <0.01). Considering cell toxicity against HepG2 cell line, C1 conjugates and C2 conjugates were more effective than C1 and C2 congeners at 10μM concentration ( p <0.05), but at higher concentrations (100 μM and 1000 μM) this activity was quite significant ( p <0.01).

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