Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient-induced pluripotent stem cell-derived retinal pigment epithelium cells.

Clin Transl Med · 2022 · PMC8926896 · PMID 35297555

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showed a trendno p-value reported

Notably, most of these DE proteins showed a trend for upregulation, and THBS1 involved in ER stress response was the most upregulated protein, suggesting an elevated UPR activity in RP11‐retinal organoids.

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