Chronic exposure to ambient traffic-related air pollution (TRAP) alters gut microbial abundance and bile acid metabolism in a transgenic rat model of Alzheimer's disease.

While a clear trend was not observed for all endpoint parameters to conclude that gut microbiome mechanistically contributes TRAP-induced neurotoxicity with unique specificity towards one sex or host genotype, it is clear that the TRAP-induced gut dysbiosis and alterations in bile acids is highly sex- and host-genotype dependent.

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