Selective modulator of nuclear receptor PPARγ with reduced adipogenic potential ameliorates experimental nephrotic syndrome.

Although Trpc6 (encoding for transient receptor potential cation channel, subfamily C, member 6) showed a trend toward induction with PAN and reduction with both Pio and GQ-16 treatments, its correlation with proteinuria was not found to be significant ( Figures 3 E and 3F).

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In this regard, designing novel modulators of PPARγ which would result in its optimal conformation that would yield desirable molecular and clinical effects would be highly significant.

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