Anticancer effects of myricetin derivatives in non-small cell lung cancer in vitro and in vivo.

While we observed that S4‐2‐2 showed a trend of an increasing number of cells with cell cycle arrest at the G1 phase, the difference was not statistically significant (Figure 5C,D ). 3.5 S4‐2‐2 suppressed A549 cells by influencing the biological behavior of NSCLC cells through the regulation of endoplasmic reticulum stress and steroid biosynthesis By comparing the transcriptional profile of A549 cells in the S4‐2‐2 and DMSO groups treated for 15 h, 860 differentially expressed genes were identified, including 541 upregulated genes and 319 downregulated genes (Figure 6A,B ).

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