More importantly, the effect of rs140570886 on Lp(a) levels remained highly significant after adjustment for the KIV-2 CNV (beta = 1.11, P = 1.94 × 10 −57 ) ( Figure 4 C , Supplementary material online, Table S10 ).
Moreover, albeit the originally discovered rs1652507 × rs9458001 interaction term became non-significant, we observed nominally significant interactions of both rs1652507 and rs9458001 with rs140570886.
These two observations reflect the marginally significant interaction coefficients between rs140570886 and rs1652507 and between rs140570886 and rs9458001 in the two- and three-way interaction model ( Supplementary material online, Table S12 ).