Beneficial Metabolic Effects of Praliciguat, a Soluble Guanylate Cyclase Stimulator, in a Mouse Diet-Induced Obesity Model.

Front Pharmacol · 2022 · PMC8931041 · PMID 35308230

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did not reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

Compared with DIO controls, plasma IL-6 was lower in lean mice (-93%) and trended to be lower in praliciguat-treated mice than in DIO control mice, although this effect did not reach statistical significance (-60%, p = 0.06, Figure 6D ).

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