Uncontrolled mitochondrial calcium uptake underlies the pathogenesis of neurodegeneration in MICU1-deficient mice and patients.

Notably, the above-described pole, grip, and rotarod results were obtained with male mice, but we also performed similar studies on a small cohort of female mice, in which the nKO showed a clear trend in all tests to a similar phenotype to what we observed in male animals (fig.

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