Barely Significant
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Nephrogenic Diabetes Insipidus following an Off-Label Administration of Sevoflurane for Prolonged Sedation in a COVID-19 Patient and Possible Influence on Aquaporin-2 Renal Expression.

Case Rep Anesthesiol · 2022 · PMC8933092 · PMID 35310519

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a significant trendno p-value reported
There was also a significant trend in an increase in serum creatinine at the end of sevoflurane administration but none of the patients developed chronic kidney injury.

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