Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox.

Nat Commun · 2022 · PMC8933454 · PMID 35304471

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Enzyme-linked immunosorbent assay (ELISA) for serum OCN further confirmed the remarkable positive effect of YB-EVs on osteogenic activity, whereas the AB-EVs-treated young and mice showed a trend of decrease in serum OCN compared with the solvent-treated control mice (Fig. 3l ).

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