We found 66 highly significant associations between V- and J-gene trimming and SNPs within the DCLRE1C gene locus for both productive and non-productive TCRs when considered in the whole-genome context.
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Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities.
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We were unable to validate the most significantly associated DNTT SNPs due to lack of overlap between the SNP sets for the discovery and validation cohorts; a discovery-cohort weakly associated SNP (rs3762093) failed to reach statistical significance for all N-insertion types, but had the same direction of effect in the validation cohort as follows.