Altered metabolome and microbiome features provide clues in understanding irritable bowel syndrome and depression comorbidity.

To further confirm potential mechanistic associations that are perturbed in IBS, we specifically focused on the subset of associations that were nominally significant ( p- value < 0.05) and changes in the same direction in healthy controls.

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Secondly, most differentially abundant species identified in the discovery cohort only trended in the same direction but did not achieve significance in the validation cohort.

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