Genetic barcoding systematically compares genes in del(5q) MDS and reveals a central role for CSNK1A1 in clonal expansion.

The fit of the model implies that Csnk1a1 haploinsufficient stem cells showed a trend toward decreased proliferation ( Figure 2B ) but increased self-renewal ( Figure 2C ) compared with WT (optimal fit of self-renewal larger than self-renewal of WT in all mice ( P < .1 in 1 mouse; Figure 2C ) and a relatively small variation among the mice.

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