Neuropsychological changes in FMR1 premutation carriers and onset of fragile X-associated tremor/ataxia syndrome.

J Neurodev Disord · 2022 · PMC8942145 · PMID 35321639

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closest p

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approached significanceno p-value reported

However, only the differential rates of change effect in motor dexterity survived multiple comparison correction, while visual working memory and manual movement speed approached significance after correction.

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marginally significantno p-value reported

Neuropsychological changes associated with FMR1 molecular measures Models examining the effect of elevated FMR1 mRNA showed a significant effect on manual reaction time in Pm (higher mRNA, worsening reaction time with age) and a marginally significant negative effect of mRNA on planning.

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