The length difference was apparent for both mRNAs and lncRNAs, and correlated with the observation that EV-enriched mRNA transcripts had shorter coding sequences (CDS) (median 783 nt for EV-enriched vs. 1905 nt for EV-depleted, p < 2.2e−16, Welch’s t -test) and 3′ UTRs (median 708 vs. 1496 nt, p = 2.9e−11, Welch’s t -test), while the length of their 5′ UTRs was not significantly different (median 176 vs. 198 nt, p = 0.374, Welch’s t -test, Additional file 4 : Fig.
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Sorting and packaging of RNA into extracellular vesicles shape intracellular transcript levels.
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