C5a and C5aR1 are key drivers of microvascular platelet aggregation in clinical entities spanning from aHUS to COVID-19.

Blood Adv · 2022 · PMC8945302 · PMID 34852172

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showed a trendno p-value reported

C5a levels were higher in serum from patients with aHUS than in serum from healthy subjects and showed a trend to decrease (albeit not significantly) at the end of the 2-week treatment with CCX168 ( Figure 1I ).

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