did not reach statistical significancep -value = 0.03
SIRs by Time after Cholecystectomy The risk of ovarian cancer increased by 35% (95% CI 2% to 77%) in the first 6 months after cholecystectomy (95% CI did not include 1), but the risk increase did not reach statistical significance after multiplicity adjustment ( p -value = 0.03, Table 1 ).