a marked trendp = 0.05
For overall survival, only the detection of ctDNA at baseline emerged as independent factor associated with shorter OS (HR: 2.3; 95% C.I.: 1.1–5.1, p = 0.041), while only gender had a marked trend (HR: 2.0, 95% C.I.: 1.0–4.1, p = 0.05). 4.