Effects of the Leptin-Mediated MAPK/ERK Signaling Pathway on Collagen II Expression in Knee Cartilage of Newborn Male Mice from Obese Maternal Offspring.

Timp1 mRNA showed a trend of increasing and then decreasing with the increasing leptin dose ( Figure 5 G, p < 0.05), while TIMP1 protein showed decreased expression under the high dose of leptin ( Figure 5 E,F, p < 0.05).

also in 53,322 other papers

A decreasing trend in collagen II expression was found in the knee cartilage of 1-month-old mice from the maternal obesity group (O-OB-1M) relative to the control group (O-WT-1M), with no statistically significant difference ( Figure 7 F, p > 0.05).

also in 47,180 other papers