Divergent Metabolic Effects of Metformin Merge to Enhance Eicosapentaenoic Acid Metabolism and Inhibit Ovarian Cancer In Vivo.

Cancers (Basel) · 2022 · PMC8946838 · PMID 35326656

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a positive trendno p-value reported

In contrast, a small pilot randomized clinical trial of metformin in combination with first-line chemotherapy did not show a meaningful effect on progression-free survival, although a positive trend was observed and the negative modulation of the pro-tumor IGF-1 signaling axis was observed [ 72 ].

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showed a trendno p-value reported

Metformin treatment showed a trend towards increased expression of 5-LOX and 15-LOX in tumors compared to the control at mRNA and protein levels ( Figure 10 C,D).

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