An Overview of Different Techniques for Improving the Treatment of Pulmonary Hypertension Secondary in Systemic Sclerosis Patients.

For example, in a multicenter, double-blind, randomized, placebo-controlled, proof-of-concept trial (n = 57), B-cell depletion with rituximab (1000 mg administered 2 weeks apart) was found to be safe and effective, and, although the primary end-point (mean of change in 6 MWD) favored treatment, this did not reach statistical significance [ 82 ]. 5.

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