The P2RX7 antagonist A740003 had a tendency to reduce the size of the tumours from both cell lines although this did not quite reach statistical significance (P = 0.0568 for MNNG-HOS + P2RX7B and P = 0.0516 for MNNG-HOS; Supplementary Fig. 2 Aii and 2Aiii).
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The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties.
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0.0568
0.0568
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4 B & 4E) but this did not reach statistical significance.