A m⁶Avalue predictive of prostate cancer stemness, tumor immune landscape and immunotherapy response.

By trying different k -means ( Supplementary Figure S2D ), three clusters were identified (with a clear trend that many writer and reader genes were upregulated in C3), including 139 patients in cluster 1 (m 6 A_C1), 39 patients in cluster 2 (m 6 A_C2) and 155 patients in cluster 3 (m 6 A_C3) (Figure 2B , left; Supplementary Table S3 ).

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Classification of patients with or without mutations in these m 6 A regulators showed that the mutant group displayed a nonsignificant trend of worse survival outcome, but significantly higher GS, over the WT group ( Supplementary Figure S1C ), suggesting a potential pro-oncogenic role for the deregulated m 6 A pathway.

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