Statins and Colorectal Cancer Risk: A Population-Based Case-Control Study and Synthesis of the Epidemiological Evidence.

All of the individual statins examined showed a trend of a reduced risk of variable magnitude without differences regarding lipophilicity, while moderate and high intensity of treatment seems to present a greater effect.

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Association of Statins with CRC by Active Principle, Lipophilicity and Intensity By active principle, we found a trend of a reduced risk with the current use of all statins, albeit statistically significant results were only reached with simvastatin (AOR = 0.86; 95% CI: 0.80–0.93) and rosuvastatin (AOR = 0.58; 95% CI: 0.41–0.83), being marginally significant for atorvastatin (AOR = 0.92; 95% CI: 0.84–1.00; Table 3 ).

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