Deficiency of myeloid PHD proteins aggravates atherogenesis via macrophage apoptosis and paracrine fibrotic signalling.

Cardiovasc Res · 2022 · PMC8953448 · PMID 33913468

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Further, all plaque macrophages—without subset divisions- showed a trend to increased SPP1 mRNA expression in single-cell analysis, while SPP1 mRNA was significantly up-regulated only in TREM2hi PHD2cko macrophages ( Figure 6 G and H ).

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