Metformin Enhances TKI-Afatinib Cytotoxic Effect, Causing Downregulation of Glycolysis, Epithelial-Mesenchymal Transition, and EGFR-Signaling Pathway Activation in Lung Cancer Cells.

Pharmaceuticals (Basel) · 2022 · PMC8955777 · PMID 35337178

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an increasing trendno p-value reported

We did not find any significant change in all cell lines; however, we note an increasing trend in some subunit levels.

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showed a trendno p-value reported

We found that metformin can sensitize TKI-resistant LC cells H1975, which showed a trend towards increased cytotoxic induction by TKI-afatinib.

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