Comprehensive characterization of PTEN mutational profile in a series of 34,129 colorectal cancers.

In contrast, there is highly significant mutual exclusion between PTEN deletions and PI3KCA mutations (Fig. 8d ), sharply distinguishing this class of PTEN mutations from other classes.

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In MT-H tumors, the overall increase of prevalence of PTEN alterations by age did not reach statistical significance, and did not vary by sex; but there were markedly different age trends by subsite (Supplementary Fig. 2d, e and Supplementary Tables 7 – 9 ).

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