Polygenic Risk Score Effectively Predicts Depression Onset in Alzheimer's Disease Based on Major Depressive Disorder Risk Variants.

Front Neurosci · 2022 · PMC8957806 · PMID 35350557

Europe PMC DOI

hedged sentence

0.5510

closest p · 11.0× alpha

0.5510

boldest claim

The sentences

did not reach statistical significanceP = 0.551not close (p > 0.1)

In this full model analysis, baseline age (beta = –0.018, P = 0.0049) and sex (beta = –0.251, P = 9e-5) showed significant effects ( Figure 4B ), but PRS ( P Threshold = 0.005) did not reach statistical significance (beta = –0.038, P = 0.551; Supplementary Table 17 ).

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