Efficacy and safety of direct oral anticoagulants with and without Aspirin: A systematic review and Meta-analysis.

Additionally, death as an outcome also demonstrated a significant trend in favor of DOAC monotherapy (RR = 1.33 [1.05, 1.68]; p = 0.02; I 2 = 19%). 4 Discussion In this extensive meta -analysis comprising more than 50 000 patients, DOAC monotherapy significantly reduced the risk for major bleeding compared with combination therapy with DOAC and ASA.

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