Reduced cortical cholinergic innervation measured using [¹⁸F]-FEOBV PET imaging correlates with cognitive decline in mild cognitive impairment.

For the performance in memory, the correlation with the global FEOBV SUVR was close to the level of significance ( r = 0.502, p = 0.057). 3.3 Voxel-Wise analysis of FEOBV PET across cognitive domains Significant FEOBV SUVR reductions (TFCE-corrected p < 0.05) among the participants with MCI comparing to the CU individuals were found in a small focal cluster (1.2 ml ) near the middle temporal gyrus in the right hemisphere ( t -value = 4.583 ± 0.597, Fig. 3 ).

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